LSD is being used to treat chronic pain and a number of psychiatric indications, including anxiety, depression, treatment resistant depression (TRD), post-traumatic stress disorder (PTSD), attention-deficit/hyperactivity disorder (ADHD), alcoholism, cluster headaches, and mood disorders.

Individual studies report various findings, depending on study design, dose, predisposition of the participants in terms of mental health or life-threatening disease. While studies have investigated a variety of other factors, such as set and setting, and the “expectancy effect” (if you think you expect LSD to help you, it has a higher chance of helping you), overall the findings on LSD as a potential therapy are generally positive. But it is important to remember that LSD in a non clinical setting may produce different results than the research findings.

Research suggests that LSD may be effective in breaking cycles of depression, addiction, and other mental conditions. This is at least in part, due to the compound’s ability to connect areas of the brain that don’t ordinarily communicate with each other, while sometimes losing the connective integrity of other mental processes.