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Substances
Discover the plants, fungi and compounds that create non-ordinary forms of awareness and expanded states of consciousness.
To learn best practices developed by harm reduction experts for the novice and intrepid psychonaut alike, start here.
Ketamine
Ketamine is a legal dissociative anesthetic that is used off-label in clinics for conditions including depression and trauma.
LSD
LSD is a potent synthetic psychedelic substance which has had a profound impact on culture, science and spirituality.
MDMA
MDAM (also "Ecstasy" or "Molly") is a potent empathogen with effects that include altered sensations, increased energy, empathy, and pleasure.
Psilocybin Mushrooms
Psilocybin mushrooms, sometimes called magic mushrooms or "shrooms" for short, are a class of psychedelic fungi that grow naturally around the world.
Top Questions
- Are magic mushrooms legal where I live?
- Can ketamine treat depression?
- What are the benefits of microdosing magic mushrooms?
- How much magic mushrooms should I take?
- Can MDMA treat PTSD?
The answer varies depending on your location. Check out our guide to helping you navigate your local policies.
Studies suggest ketamine-assisted therapy is a promising treatment for depression due to its fast-acting ability to relieve depressive symptoms.
Some people report feeling increased focus, reduced anxiety, and an improved sense of wellbeing.
Everyone is affected differently, and there are many different species and strains. However, there are general ranges recommended for light, moderate, and heavy experiences.
MDMA-assisted therapy has the potential to treat PTSD due to its effects on the amygdala, the part of the brain that processes fear that’s overactive in PTSD patients.
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Ketamine for Pain
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Ketamine for Conditions
UPDATED: August 2nd, 2023
Ketamine is being used to treat an array of mental health conditions and substance…
Ketamine-Assisted Therapy
UPDATED: August 2nd, 2023
Long used as an anesthetic, the use of ketamine as a possible therapeutic agent…
Ketamine in Combination with Other Substances
UPDATED: July 31st, 2023
Ketamine is often combined with other drugs to create an amplified dissociative or psychedelic…
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UPDATED: July 21st, 2023
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